Vaccination is an age long science that has been proven to prevent some deadly diseases, especially in children below the age of 5years. Therefore, it is empirical for any nation to stimulate the process of immunization and ensure that children and adults are protected from some of these infectious and deadly diseases. This will bring about a safe, healthy, and productive society where every individual within the system contributes their quota to the Gross Domestic Product (GDP) rather than treating the overall consequences of the lack of vaccination.This research work was initiated to critically consider the limitations that impact local manufacturing of vaccines in Nigeria. A review of various literature from articles, journals, workshop presentations at different scientific conferences and other sources on related topics, to see trends and events as it relates to effort made in local vaccines manufacturing. From the literature reviewed, it was evident that most of the vaccines production are from developed countries like china, India, Russia, Vietnam, United States of America, Europe with very few Africa countries currently manufacturing vaccines locally.In this research, qualitative method and Interpretivism philosophy of interviews arranged with experts on this subject matter were employed. Due to the prevailing pandemic ravaging the world, the researcher could not have a face-to-face interview with the identified experts contacted to be part of this research. Therefore, zoom meetings were set up and responses to the questions asked were all recorded and transcribed during the data analysis process. This process adequately ensured that the data collection process was effectively managed and with the use of thematic analysis, which is considered the most effective and preferred method used in qualitative data analysis based on its enormous benefits.From the data analyzed using the answers provided by the experts interviewed in this research work, some findings inferred. There is no vaccine currently manufactured locally in Nigeria. Advocacy could be considered a strong tool in achieving local manufacturing of vaccines. There are available government policies on local manufacturing of vaccines, but the problem majorly is the lack of policy implementation.Although the pharmaceutical industries are willing to engage in local manufacturing of vaccines. Also, the challenges facing the pharmaceutical industries in achieving local manufacturing of vaccines are numerous but could be upturned with government support. My researcher work has been able to identify some solution through the various recommendations and suggestions as discussed in chapter 5 of this dissertation. If these highlighted issues are implemented, then achieving local manufacturing of vaccines could be easily achieved and in good time.