This study examined the awareness, usage, and barriers related to Home-Based Medical Devices (HBMDs), such as glucometers and blood pressure monitors, among patients with diabetes and hypertension in Pakistan. The findings indicated that awareness and utilization of HBMDs were generally low, particularly among rural and underserved populations. Semi-structured interviews were conducted with healthcare professionals, including general practitioners, cardiologists, and endocrinologists, who confirmed that patients often lacked the knowledge, training, and confidence required for effective use of these devices. Additionally, the results revealed that the adoption of HBMDs was significantly hindered by cultural resistance, high costs, limited digital literacy, and concerns regarding data privacy. Furthermore, although healthcare professionals were identified as crucial in promoting the use of these devices, many lacked the necessary resources and training to adequately support patients. According to the findings, enhancing the adoption of HBMDs in Pakistan necessitated a coordinated strategy that included focused patient education, affordability-enhancing subsidies, culturally appropriate awareness campaigns, professional development for healthcare professionals and strengthened safeguards for patient data. These findings offer valuable insights for policymakers and healthcare professionals aiming to improve chronic disease management through the use of home-based medical technology.