The issue of counterfeit drugs poses a major threat to the health and wellbeing of the public, especially in Nigeria where the prevalence of substandard and falsified medicines is alarmingly high. This research focused on how pharmacists can play a part in enhancing drug quality. The study population of this study comprises registered pharmacists across Nigeria, chosen due to their vital place within both pharmaceutical supply chains as well as their direct engagement with consumers and manufacturers alike. A stratified random sampling technique was employed to select four states in Nigeria (Lagos, Rivers, Kano, and Oyo states) and 160 pharmacists working in Federal, State, and Local Government Areas hospitals were selected using simple random sampling, ensuring representation from various regions and settings, including urban, rural, and semi-urban areas. A structured questionnaire administered through Google Form was used as instrument to collect data on pharmacists’ experiences with counterfeit drugs, their knowledge of drug quality control measures, and their perceptions of the effectiveness of current regulatory frameworks. The hypotheses were tested using Pearson correlation and linear regression and the demographic characteristics were analysed using descriptive analysis (charts and frequency tables). The results also indicate that while pharmacists are generally knowledgeable about drug quality and control, many face challenges in implementing these measures due to factors such as inadequate resources, limited access to reliable testing equipment, and insufficient support from regulatory bodies. This study also highlights the critical role that pharmacists play in identifying and reporting counterfeit drugs, as well as in educating consumers about the dangers of substandard medications. However, the study also found the need for stronger collaboration between pharmacists, regulatory agencies, and other stakeholders in the pharmaceutical industry to effectively combat the counterfeit drug crisis. The study concludes that pharmacists' engagement in public awareness campaigns and using of advanced technological tools will significantly improve drug quality in Nigeria. And there is a significant relationship between public awareness campaigns and counterfeit drug prevention. This study also concludes that stronger regulatory frameworks are significantly effective in preventing the circulation of counterfeit drugs in Nigeria. Based on the findings of this study, it is recommended that the government should intensify efforts to crack down on the production and distribution of counterfeit drugs by increasing surveillance and implementing more severe penalties for offenders. iv Additionally, affordable and user-friendly technology should be given priority investments to ensure broad usage across all regions where there are practising pharmacists.