The Gut Microbiome is a community of microorganisms that colonise together in the gastrointestinal tract to play a crucial role in the body’s immune defence, behaviour, and metabolism. The Gut Microbiome has been linked to the development of many gut dysbiosis related diseases including Crohn’s disease and Colitis. As there is currently no cure for these diseases, treatment for the alleviation of associated symptoms is crucial for patient quality of life. Faecal Microbiota Transplantation is a restorative therapeutic technique involving the transplantation of healthy donor faecal bacteria to a receiving patient with the aim of altering their Gut Microbiome to resemble that of their donor’s. The objective of this research was to investigate how alteration of the Gut Microbiome with Faecal Microbiota Transplantation can be used in modern Western medicine as an effective disease treatment method for Crohn’s Disease and Colitis.

This thesis compared the effectiveness of Faecal Microbiota Transplantation to current, conventional disease treatment methods via secondary research through analysis of recently published scientific journals and other reliable government and non-governmentbased sources.

A major observation from this research was that patients undergoing Faecal Microbiota Transplantation showed higher success rates when higher levels of Faecalibacterium prausnitzii were present in their Gut Microbiome post treatment. Going forward, an extra step should be added to the donor screening process to help determine the presence of Faecalibacterium prausnitzii in the donor sample before its acceptance as suitable for donation. This will help increase both the receiver’s treatment success rate and patience

acceptance of the disease treatment method.

In conclusion, this thesis adds to the overall collective knowledge of the use of Faecal Microbiota Transplantation and gives evidence to its massive future potential as an effective main-stage, first-time disease treatment method in modern Western medicine for the alleviation of Crohn’s Disease and Colitis symptoms