The ongoing human health studies concerning the use of Titanium Dioxide in the food industry has been explored in many literature studies. The European Commission have recently declared a full ban of Titanium Dioxide (E171) as a food and feed additive in the European Union with the six month phasing out period from 07 February 2022 until 07 August 2022 effectively. Following this ban, there is a huge demand for alternatives within the food industry sector and also challenges that comes with this change. The aim of this thesis is to investigate the health implications that TiO₂ has brought about this ban, exploring the alternatives that the food companies have innovated in order to tackle this challenge. The key findings were that there are many in invo and in vitro studies concerning human ingestion and inhalation however no real human studies completed. The Food industry is continuously innovating on their own portfolio to create a close match to the appearance whitening effect of TiO₂. In conclusion, there has been a huge progress and response of the companies due to this change, however there is a need to explore further alternatives in the future.