In this study, it was revealed that uptake of mRNA vaccines in Ireland is shaped by a complex interplay of demographic, social, and informational determinants. In the context of the COVID19 pandemic, a data-driven approach was employed to establish the determinants of vaccine uptake, to inform public health policy. A cross-sectional quantitative survey was conducted among students, parents, healthcare workers, and the general population. Information was captured on the history of vaccination among respondents, willingness to receive future mRNA vaccines, familiarity with vaccine technology, perceived adverse effects, and trust in various sources of information. The results showed that overall mRNA vaccine acceptance was high but with persistent hesitancy among some subgroups due to safety concerns, apprehensions over long-term adverse effects, and a lack of understanding about how mRNA works. Participants who relied on health professionals and official health bodies as primary sources of information had the highest levels of acceptance. On the other hand, participants exposed primarily to vaccine-related information on social media or through word of mouth were more likely to be sceptical or hesitant. Misinformation, especially on social media, emerged as a significant stimulant for scepticism and confusion. The findings underscore the need for clear, open, and accessible public health communication in supporting vaccine confidence. The health institution and professional trust greatly boosted willingness to get mRNA vaccines, and hence the value of bringing in trusted individuals as part of future outreach efforts. Targeted communication that addresses directly held concerns, particularly in high-hesitancy populations such as those in rural or underserved settings, is essential. Equipping healthcare professionals with tools and training to address misinformation and encourage informed decision-making is advised by the research. While the study provided valuable quantitative findings, additional research employing qualitative or longitudinal study designs is suggested to determine shifting public opinion and underlying psychological reasons for vaccine hesitancy. The findings provide pragmatic recommendations for designing effective communication programs and enhancing public trust in vaccine programs in Ireland and other regions