Improper disposal of unused and expired medicines poses significant risks to public health and the environment, particularly in areas like Kerala, India, where structured disposal systems are lacking. This research investigates the possibility of introducing a pharmacy-led medication takeback initiative in Kerala, inspired by the CYCLAMED program successfully implemented in France. The study utilized a quantitative methodology, collecting data from pharmacists in diverse settings across Kerala to assess existing disposal habits, awareness levels, practical challenges, and readiness for such a program. Additionally, secondary sources were reviewed to examine the operational strengths and outcomes of the CYCLAMED model. Findings show strong support among pharmacists for a take-back initiative, with 73% willing to participate and over 70% believing their pharmacies have the resources to implement the system. Nonetheless, several challenges were identified, including unclear regulatory frameworks, limited public awareness, inadequate infrastructure, and financial constraints. Rural pharmacies, in particular, reported lower preparedness, emphasizing the need for tailored approaches in these regions. A majority of respondents highlighted the importance of government-led education campaigns, clear regulatory framework, and financial assistance as key enablers of success. Overall, the study concludes that a pharmacy-led take-back system is both practical and needed in Kerala, provided that current gaps are addressed through coordinated policy, regulatory reform, and community engagement. Drawing insights from international practices, the research recommends a comprehensive strategy involving collaboration between healthcare stakeholders, government authorities, and the public. Such a system could play a crucial role in improving pharmaceutical waste management, safeguarding public health, and promoting environmental sustainability in the region.