Chemotherapy-induced alopecia is a common and psychologically distressing side effect of cancer treatment, with a major influence on patients' quality of life. Studies have shown that scalp cooling devices have the potential to reduce chemotherapy-related hair loss. This study aims to examine public awareness, attitudes, and willingness to use scalp cooling devices in Southern India, while also addressing cultural, economic, and informational barriers. It also seeks feedback on potential device improvements to enhance accessibility and acceptance in oncology care. Motivated by a clear knowledge gap surrounding the use of scalp cooling in Southern India, this study employed a mixed-methods approach to collect both quantitative and qualitative data. A survey was distributed, focusing general population, including healthcare professionals, and individuals affected by cancer. Descriptive statistical analysis and visualisation were performed using Microsoft Excel and Minitab, while thematic analysis was used to analyse open-ended responses and identify recommendations from participants. Key findings indicate that public awareness of scalp cooling devices in Southern India is low, with many respondents hearing about the technology for the first time during the survey. However, after being informed, a majority expressed positive attitudes and interest in the potential emotional benefits of reducing hair loss during chemotherapy. Participants identified high cost, limited access to information, and discomfort with the device design as key barriers to adoption. Also, suggested that increasing affordability through subsidies or insurance, expanding local access, and providing clearer information on effectiveness and safety could improve adoption. The study highlights the need for awareness campaigns, training programs for healthcare providers, and the provision of financial assistance programs to improve access and adoption of these devices. By addressing the notable gap in understanding regarding the awareness and use of scalp cooling devices in Southern India, this study enhances regional knowledge, offers practical recommendations for healthcare providers, policymakers, and manufacturers, and lays the groundwork for future studies on medical device adoption in India and comparable settings